Welcome to the Veglia Group

The central theme of our research is calcium regulation and cAMP-mediated cell signaling in cardiac and skeletal muscle, which are orchestrated by both soluble enzymes and integral membrane proteins. Specifically, we utilize a multidisciplinary approach combining NMR spectroscopy, calorimetry, biochemical assays, molecular dynamics simulation, chemical biology and recombinant protein expression to study the structure and conformational dynamics of several proteins of central importance in heart disease, cancer and non-shivering thermogenesis. In particular, the lab specializes extensively in the application and theoretical development of solution and solid-state NMR spectroscopic methods to unravel allosteric pathways regulating the activity of kinases and determination of the structure and topology of membrane proteins in their native lipid bilayer environment.

Veglia Lab Photo