Publications from 2015 to present

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For reprints of publications or additional information, please contact Gianluigi Veglia at [email protected].

Publications Prior to 2015

119. Srivastava A., McDonald L., Cembran A., Kim J., Masterson L., McClendon C., Taylor S., Veglia G.Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling.Structure 2014, 22, 1735.

118. Cero C., Vostrikov V., Verardi R., Severini C., Gopinath T., Braun P., Sassano M., Gurney A., Roth B., Vulchanova L., Possenti R., Veglia G., Bartolomucci A. “The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism.Structure 2014, 22, 1744-53.

117. De Simone A., Mote K., Veglia G. “Structural dynamics and conformational equilibria of SERCA regulatory proteins in membranes by solid-state NMR restrained simulations.Biophys J. 2014, 106, 2566-76.

116. Chao F., Kim J., Xia Y., Milligan M., Rowe N., Veglia G. “FLAMEnGO 2.0: An enhanced fuzzy logic algorithm for structure-based assignment of methyl group resonances.J. Magn. Reson. 2014, 245, 17-23.

115. Fusco G., De Simone A., Gopinath T., Vostrikov V., Vendruscolo M., Dobson C., Veglia G.Direct observation of the three regions in α-synuclein that determine its membrane-bound behavior.Nat. Commun. 2014, 5, 3827.

114. Vostrikov V., Veglia G.Structural topologies of phosphorylated and non-phosphorylated oligomeric phospholamban in lipid membranes by a hybrid NMR approach.Advances in Biological Solid-State NMR: Proteins and Membrane-Active Peptides 2014, Chapter 22, 425-43.

113. Jing M., Verardi R., Veglia G., Bowser M. “Development of a sensitive assay for SERCA activity using FRET detection of ADP. Anal. Methods  2014, 6, 1468-1474.

112. Cembran A., Kim J., Gao J., Veglia G.NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding.Phys. Chem. Chem. Phys. 2014, 16, 6508-6518.

111. Vostrikov V. V., Mote K. R., Verardi R., Veglia G.Structural Dynamics and Topology of Phosphorylated Phospholamban Homopentamer Reveal Its Role in the Regulation of Calcium Transport.Structure 2013, 21, 1-12.

110. Gustavsson M., Verardi R., Mullen D. G., Mote  K. R., Traaseth, N. J., Gopinath T., Veglia G.Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban.Proc. Natl. Acad. Sci. USA 2013, 110, 17338-43.

109. Eggimann B., Vostrikov V. V., Veglia G., Siepmann I. “Modeling helical proteins using residual dipolar couplings, sparse long-range distance constraints and a simple residue-based force field.Theor. Chem. Acc. 2013, 132, 1388.

108. Porcelli F., Ramamoorthy A., Barany G., Veglia G.On the role of NMR spectroscopy for characterization of antimicrobial peptides.Methods Mol. Biol. 2013, 1063, 159-180.

107. De Simone A., Gustavsson M., Montalvao R.W., Shi L., Veglia G., Vendruscuolo M. “Structures of the Excited States of Phospholamban and Shifts in their Populations upon Phosphorylation.Biochemistry. 2013, 52, 6684-6694.

106. Mote K. R., Gopinath T., Veglia G.Determination of structural topology of a membrane protein in lipid bilayers using polarization optimized experiments (POE) for static and MAS solid state NMR spectroscopy.J. Biomol. NMR. 2013, 57, 91-102.

105. Gopinath T., Mote K. R., Veglia G.Sensitivity and Resolution Enhancement of Oriented Solid-State NMR: Application to Membrane Proteins.Prog. Nucl. Magn. Reson. Spectrosc. 2013, 75, 50-68.

104. Veglia G., Cembran A. “Role of Conformational Entropy in the Activity and Regulation of the catalytic subunit of Protein Kinase A.FEBS J. 2013, 22, 5608-15.

103. Gopinath T., Veglia G.Orphan spin operators enable the acquisition of multiple 2D and 3D magic angle spinning solid-state NMR spectra.J. Chem. Phys. 2013, 138, 184201.

102. Chao F., Morelli A., Haughner J.C. III, Churchfield L., Hagmann L. N., Shi L., Masterson L. R., Sarangi R.,Veglia G., Seelig B.Structure and dynamics of a primordial catalytic fold generated by in vitro evolution.Nat. Chem. Biol. 2013, 9, 81-83.

101. Veglia G., Traaseth N.J., Shi L., Verardi R., Gopinath T., Gustavsson M. “The Hybrid Solution/Solid-State NMR Method for Membrane Protein Structure Determination. Comprehensive Biophysics (ed. Egelman, E.H.) 2012, 1, 182-198. 

100. Cembran A., Masterson L.R., McClendon C. L., Taylor S. S., Gao J., Veglia G.Conformational Equilibrium of N-Myristoylated cAMP-Dependent Protein Kinase A by Molecular Dynamics Simulations.Biochemistry. 2012, 51, 10186-10196.

99. Verardi R., Traaseth N.J., Masterson L.R., Vostrikov V.V., Veglia G. “Isotope labeling for Solution and Solid State NMR Spectroscopy of Membrane Proteins.Adv. Exp. Med. Biol. 2012, 992, 35-62. 

98. Ha K.N., Gustavsson M., Veglia G. “Tuning the Structural Coupling Between the Transmembrane and Cytoplasmic Domains of Phospholamban to Control Sarcoplasmic Reticulum Ca(2+)-ATPase (SERCA) Function.J. Muscle Res. Cell Motil. 2012, doi:10.1007/s10974-012-9319-4.

97. Mullen D., Verardi R., Porcelli F., Scaloni A., Barany G., Veglia G. “Synthesis and Characterization of the 47-residue Heterodimeric Antimicrobial Peptide Distinctin, Featuring Directed Disulphide Bridge Formation.J. Pept. Sci. 2012, 98, 479-484.

96. Simonetti O., Cirioni O., Ghiselli R., Goteri G., Orlando F., Monfregola L., De Luca S., Zizzi A., Silvestri C., Veglia G., Giacometti A., Guerrieri M., Offidani A. Scaloni A. “Antimicrobial properties of Distinctin in an experimental model of MRSA-infected wounds.Eur. J. Clin. Microbiol. Infect. Dis. 2012, 31, 3047-55.

95. Masterson L.R., Cembran A., Shi L., Veglia G. “Allostery and Binding Cooperativity of the Catalytic Subunit of Protein Kinase A by NMR Spectroscopy and Molecular Dynamics Simulations.Adv. Prot. Chem. Struct. Biol. 2012, 87, 363-89.

94. Gopinath T., Veglia G.  “3D DUMAS: Simultaneous acquisition of three-dimensional magic angle spinning solid-state NMR experiments of proteins.J. Magn. Res. 2012, 220, 79-84.

93. Traaseth N.J., Chao F.A., Masterson L.R., Mangia S., Garwood M., Michaeli S., Seelig B., Veglia G. “Heteronuclear Adiabatic Relaxation Dispersion (HARD) for Quantitative Analysis of Conformational Dynamics in Proteins.J. Magn. Res. 2012, 219, 75-82.

92.   Becucci L, Papini M., Verardi R., Veglia G., Guidelli R. “Phospholamban and its phosphorylated form require non-physiological transmembrane potentials to translocate ions.Soft Matter 2012, 8, 3881-3888.

91. Gopinath T., Veglia G.Dual Acquisition Magic-Angle Spinning Solid-State NMR-Spectroscopy: Simultaneous Acquisition of Multidimensional Spectra of Biomacromolecules.Angew Chem Int Ed Engl. 2012, 51, 2731-2735.

90. Chao F.A., Shi L., Masterson L.R., Veglia G.FLAMEnGO: A fuzzy logic approach for methyl group assignment using NOESY and paramagnetic relaxation enhancement data.J. Magn. Reson. 2012, 214, 103-10.

89. Gustavsson M., Traaseth N.J., Veglia G.Probing ground and excited states of phospholamban in model and native lipid membranes by magic angle spinning NMR spectroscopy.Biochim. Biophys. Acta 2012, 18, 146-53.

88. Gustavsson M., Traaseth N.J., Veglia G.Activating and Deactivating Roles of Lipid Bilayers on the Ca2+-ATPase/Phospholamban Complex.Biochemistry 2011, 50, 10367-74. PMCID: PMC3487395

87. Mote K.R., Gopinath T., Traaseth N.J., Kitchen J., Gor’kov P.L., Brey W.W., Veglia G.Multidimensional oriented solid-state NMR experiments enable the sequential assignment of uniformly 15N labeled integral membrane proteins in magnetically aligned lipid bilayers.J. Biomol. NMR 2011, 51, 339-46.

86. Al-Abdul-Wahid M.S., Verardi R., Veglia G., Prosser R.S.Topology and immersion depth of an integral membrane protein by paramagnetic rates from dissolved oxygen.J. Biomol. NMR 2011, 51, 173-83.

85. Gopinath T., Mote K.R., Veglia G.Proton evolved local field solid-state nuclear magnetic resonance using Hadamard encoding: theory and application to membrane proteins.J. Chem Phys. 2011, 135, 074503.

84. Becucci L, Papini M, Mullen D, Scaloni A, Veglia G., Guidelli R.Probing membrane permeabilization by the antimicrobial peptide distinctin in mercury-supported biomimetic membranes.Biochim. Biophys. Acta 2011, 1808, 2745-52.

83. Masterson L.R., Yu T., Lei S., Wang Y., Gustavsson M., Muller M.M., Veglia G.cAMP-Dependent Protein Kinase A Selects the Excited State of the Membrane Protein Substrate Phospholamban.J. Mol. Biol. 2011, 412, 155-164.

82. Gaffarogullari E.C., Masterson L.R., Metcalfe E.E., Traaseth N.J., Balatri E., Musa, M.M., Mullen D., Distefano M.D., Veglia G.A myristoyl/phosphoserine switch controls cAMP-Dependent Protein Kinase A Association to the Membranes.J. Mol. Biol. 2011, 411(4):823-36.

81. Porcelli F., Oliveri C., Masterson L.R., Wang Y., Veglia G.Templating α-amylase peptide inhibitors with organotin compounds.”  J. Biol. Inorg. Chem. 2011, 16, 1197-1204.

80. Verardi R., Shi L., Traaseth N.J., Walsh N., Veglia G.Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method.Proc. Natl. Acad. Sci. USA 2011, 108(22):9101-6.

79. Traaseth N., Veglia G., “Frequency-Selective Heteronuclear Dephasing and Selective Carbonyl Labeling to Deconvolute Crowded Spectra of Membrane Proteins by Magic Angle Spinning NMR.J. Mag. Res. 2011, 211, 18-24.

78. Masterson L.R., Shi L., Metcalfe E.E., Gao  J., Taylor S.S., Veglia G.Dynamically Committed, Uncommitted, and Quenched States Encoded in Protein Kinase A Revealed by NMR Spectroscopy.Proc. Natl. Acad. Sci. USA 2011, 108(17):6969-74.

77. Gustavsson M.B., Traaseth N.J., Karim C.B., Lockamy E.L., Thomas D.D., Veglia G.Lipid-Mediated Folding/Unfolding of Phospholamban as a Regulatory Mechanism for the Sarcoplasmic Reticulum Calcium ATPase.J. Mol. Biol. 2011, 408(4):755-65.

76. Shi L., Traaseth N.J. Verardi R., Gustavsson M.B., Gao J., Veglia G.Paramagnetic-Based Restraints Lift Residual Dipolar Coupling Degeneracy in Multidomain Detergent-Solubilized Membrane Proteins.J. Am. Chem. Soc. 2011, 133(7):2232-41.

75. Ha K.N., Masterson L.R., Zhanjia H., Verardi R., Walsh N., Veglia G., Robia S.A Lethal Arg9Cys Phospholamban Mutation Hinders Ca2+-ATPase Regulation and Phosphorylation by Protein Kinase A.Proc. Natl. Acad. Sci. USA 2011, 108(7):2735-40.

74. Mullen D., Kyro K., Hauser M., Gustavsson M., Veglia G., Becker J.M., Naider F., Distefano M.Synthesis of a-Factor Peptide from Saccharomyces Cerevisiae and Photoactive Analogs via Fmoc Solid-Phase Methodology.Bioorg. Med. Chem. 2011, 19(1):490-7. PMCID: PMC3037452

73. Verardi R., Traaseth N.T., Shi L., Porcelli F., Monfregola L., De Luca S., Amodeo P., Veglia G., Scaloni A. “Probing Membrane Topology of the Antimicrobial Peptide Distinctin by Solid-State NMR Spectroscopy in Zwitterionic and Charged Lipid Bilayers.Biochim. Biophys. Acta – Biomembranes 2011, 1808, 1, 34-40. PMCID: PMC2997851

72. Traaseth N.J., Gopinath T., Veglia G.On the Performance of Spin Diffusion NMR Techniques in Oriented Solids: Prospects for Resonance Assignments and Distance Measurements from Separated Local Field Experiments.J. Phys. Chem. B 2010, 114, 43, 13872-13880.

71. Masterson L.R., Cheng C., Yu T., Tonelli M., Kornev A., Taylor S.S., Veglia G.Dynamics Connect Substrate Recognition to Catalysis in Protein Kinase A.Nature Chem. Biol. 2010, 6, 11, 821-828.

70. Gopinath T., Veglia G.Improved Resolution in Dipolar NMR Spectra Using Constant Time Evolution PISEMA Experiment.Chem. Phys. Lett. 2010, 494, 1-3, 104-110.

69. Veglia G., Ha K.N., Shi L., Verardi R., Traaseth N. “What Can We Learn from a Small Regulatory Membrane Protein?Methods Mol. Biol. 2010, 654, 303-319.

68. Mangia S., Traaseth N.T., Veglia G., Garwood M., Michaeli S. “Probing Slow Protein Dynamics by Adiabatic R1(rho) and R2(rho) NMR Experiments.J. Am. Chem. Soc. 2010, 132, 29, 9979-9981.

67. Gopinath T., Verardi R., Traaseth N.J., Veglia G.Sensitivity Enhancement of Separated Local Field Experiments: Application to Membrane Proteins.J. Phys. Chem. B 2010, 114, 15, 5089-5095.

66. Gopinath T., Traaseth N.J., Mote K., Veglia G.Sensitivity Enhanced Heteronuclear Correlation Spectroscopy in Multidimensional Solid-State NMR of Oriented Systems via Chemical Shift Coherences.J. Am. Chem. Soc. 2010, 132, 15, 5357-5363.

65. Veglia G., Ramamoorthy A. Special Issue on “Membrane Protein Dynamics: Correlating Structure to Function.Biochim. Biophys. Acta 2010, 1798, 2, 65-67.

64. Traaseth N.T., Veglia G.Probing Excited States and Activation Energy for the Integral Membrane Protein Phospholamban by NMR CPMG Relaxation Dispersion Experiments.Biophys. Biochem. Acta 2010, 1798, 2, 77-81.

63. Becucci L., Guidelli R., Karim C.B., Thomas D.D., Veglia G.The Role of Sarcolipin and ATP in the Transport of Phosphate Ion into the Sarcoplasmic Reticulum.Biophys. J. 2009, 97, 10, 2693-2699.

62. Tonelli M., Masterson L.R., Cornilescu G., Markley J.L., Veglia G.One Sample Approach to Determine the Relative Orientations of Proteins in Ternary and Binary Complexes from Residual Dipolar Coupling Measurements.J. Am. Chem. Soc. 2009, 131, 40, 14138-14139.

61. Porcelli F., Triggiani D., Buck-Koehntop B., Veglia G.Pseudo-Enzymatic Dealkylation of Alkyltins by Biological Dithiols.J. Biol. Inorg. Chem. 2009, 14, 8, 1219-1225.

60. Shi L., Traaseth N.T., Verardi R., Cembran A., Gao J., Veglia G.A Refinement Protocol to Determine Structure, Topology, and Depth of Insertion of Membrane Proteins Using Hybrid Solution and Solid-State NMR Restraints.J. Biomol. NMR 2009, 44, 4, 195-205.

59. Traaseth N.T., Shi L., Verardi R., Mullen D.G., Barany G., Veglia G.Structure and Topology of Monomeric Phospholamban in Lipid Membranes Determined by a Hybrid Solution and Solid-State NMR Approach.Proc. Natl. Acad. Sci. USA 2009, 106, 25, 10165-10170.

58. Becucci L., Cembran A., Karim C.B., Thomas D.D., Guidelli R., Gao J., Veglia G.On the Function of Pentameric Phospholamban: Ion Channel or Storage Form?Biophys. J. 2009, 96, 10, L60-62.

57. Masterson L.R., Shi L., Tonelli M., Mascioni A., Mueller M.M., Veglia G.Backbone NMR Resonance Assignment of the Catalytic Subunit of cAMP-Dependent Protein Kinase A in Complex with AMP-PNP.Biomol. NMR Assign. 2009, 3, 1, 115-117.

56. Shi L., Cembran A., Gao J., Veglia G.Tilt and Azimuthal Angles of a Transmembrane Peptide: A Comparison Between Molecular Dynamics Calculations and Solid-State NMR Data of Sarcolipin in Lipid Membranes.Biophys. J. 2009, 96, 9, 3648-3662.

55. Gopinath T., Veglia G.Sensitivity Enhancement in Static Solid-State NMR Experiments via Single- and Multiple-Quantum Dipolar Coherences.J. Am. Chem. Soc. 2009, 131, 16, 5754-5756.

54. Masterson L.R., Bortone N., Yu T., Ha K.N., Gaffarogullari E., Nguyen O., Veglia G.Expression and Purification of Isotopically Labeled Peptide Inhibitors and Substrates of cAMP-dependent Protein Kinase A for NMR Analysis.Protein Expr. Purif. 2009, 64, 2, 231-236.

53. Nanga R.P., Brender J.R., Xu J., Veglia G., Ramamoorthy A.Structures of Rat and Human Islet Amyloid Polypeptide IAPP(1-19) in Micelles by NMR Spectroscopy.Biochemistry  2008, 47, 48, 12689-12697.

52. Behling L.A., Hartsel S.C., Lewis D.E., Dispirito A.A., Choi D.W., Masterson L.R., Veglia G., Gallagher W.H.NMR, Mass Spectrometry, and Chemical Evidence Reveal a Different Chemical Structure for Methanobactin that Contains Oxazolone Rings.J. Am. Chem. Soc. 2008, 130, 38, 12604-12605. 

51. Masterson L.R., Tonelli M., Markley J.L, Veglia G.Simultaneous Detection and Deconvolution of Congested NMR Spectra Containing Three Isotopically Labeled Species.J. Am. Chem. Soc. 2008, 130, 25, 7818-7819.

50. Porcelli F., Verardi R., Shi L., Henzler-Wildman K.A., Ramamoorthy A., Veglia G.NMR Structure of the Cathelicidin-derived Human Antimicrobial Peptide LL-37 in Dodecylphosphocholine Micelles.Biochemistry 2008, 47, 20, 5565-5571.

49. Deng Y., Wang Y., Holtz B., Li J., Traaseth N.J., Veglia G., Stottrup B.J., Elde R., Pei D., Guo A., Zhu X.Y.Fluidic and Air-stable Supported Lipid Bilayer and Cell-mimicking Microarrays.J. Am. Chem. Soc. 2008, 130, 19, 6267-6271.

48. Traaseth N.J., Verardi R., Veglia G.Asymmetric Methyl Group Labeling as a Probe for Membrane Protein Homo-oligomers by NMR Spectroscopy.J. Am. Chem. Soc. 2008, 130, 8, 2400-2401.

47. Masterson L.R., Mascioni A., Traaseth N.J., Taylor S.S., Veglia G.Allosteric Cooperativity in Protein Kinase A.Proc. Natl. Acad. Sci. USA 2008, 105, 2, 506-511.

46. Traaseth N.J., Ha K, Verardi R., Shi L., Buffy J.J., Masterson L.R., Veglia G.Structural and Dynamic Basis of Phospholamban and Sarcolipin Inhibition of Ca2+-ATPase (SERCA).Biochemistry 2008, 47, 1, 3-13.

45. Ha K., Traaseth N.J., Verardi R., Zamoon J., Cembran A., Karim C.B., Thomas D.D., Veglia G.  “Controlling the inhibition of the sarcoplasmic Ca2+-ATPase by tuning phospholamban structural dynamics.J. Biol. Chem. 2007, 282, 51, 37205-37214.

44. Traaseth N.J., Verardi R., Torgersen K.D., Karim C.B., Thomas D.D., Veglia G.Spectroscopic Validation of the Pentameric Structure of Phospholamban.Proc. Natl. Acad. Sci. USA 2007, 104, 37, 14676-81.

43. Tonelli M., Masterson L.R., Veglia G., Markley J.L.Carbonyl Carbon Label Selective (CCLS) 1H-15N HSQC Experiment for Backbone Assignments of Proteins Incorporating Pairs of 15N- and 13C’- Labeled Amino Acids.J. Biomol. NMR 2007, 39, 3, 177-185.

42. Masterson L.R., Etienne M.A., Porcelli F., Barany G., Hammer R.P., Veglia G.Non-stereogenic α-aminoisobutyryl-glycyl (Aib-Gly) Dipeptidyl Unit Nucleates Type I' β-turn in Linear Peptides in Aqueous Solution.Biopolymers 2007, 88, 5, 746-53.

 41. Sibert R., Josowicz M., Porcelli F., Veglia G., Range K., Barry B.A.Proton-Coupled Electron Transfer in a Biomimetic Peptide as a Model of Enzyme Regulatory Mechanisms.J. Am. Chem. Soc. 2007, 129, 4393-4400.

40. Becucci L., Guidelli R., Karim C.B., Thomas D.D., Veglia G.An Electrochemical Investigation of Sarcolipin Reconstituted into a Mercury-Supported Lipid Bilayer.Biophys. J. 2007, 93, 8, 2678-2687.

39. Gor’kov P.L., Chekmenev E. Y., Conggang L., Cotton M., Buffy J.J., Traaseth N.J., Veglia G., Brey W.W. “Using low-E resonators to reduce RF heating in biological samples for static solid-state NMR up to 900 MHz.J. Magn. Res. 2007, 185, 77-93.

38. Traaseth N.J., Buffy J.J., Zamoon J., Veglia G.Structural Dynamics and Topology of Phospholamban in Oriented Lipid Bilayers using Multi-dimensional Solid-State NMR.Biochemistry 2006, 45, 13827-34.

37. Buffy J.J., Traaseth N.J., Mascioni A., Gor’kov P.L., Chekmenev E.Y., Brey W.W., Veglia G. “Two-Dimensional Solid-State NMR Reveals Two Topologies of Sarcolipin in Oriented Lipid Bilayers. Biochemistry 2006, 45, 10939-46.

36. Porcelli F., Buck-Koehntop B. A., Thennarasu S., Ramamoorthy A., Veglia G. Structures of the Dimeric and Monomeric Variants of Magainin Antimicrobial Peptides (MSI-78 and MSI-594) in Micelles and bilayers by NMR Spectroscopy.Biochemistry 2006, 45:5793-5799.

35. Buck-Koehntop B. A., Porcelli F., Lewin J.L., Cramer C.J., Veglia G.Biological Chemistry of Organotin Compounds: Interactions and Dealkylation by Dithiols.J. Organometal. Chem. 2006, 691:1748-1755.

34. Traaseth N.J., Thomas D.D., Veglia G.Effects of Ser16 Phosphorylation on the Allosteric Transitions of Phospholamban/Ca2+-ATPase Complex.J. Mol. Biol. 2006, 358:1041-50.

33. Buffy J.J., Buck-Koehntop B. A., Porcelli F., Traaseth N. J. Thomas D. D., Veglia G.Defining the Intramembrane Binding Mechanism of Sarcolipin to Calcium ATPase Using Solution NMR Spectroscopy.J. Mol. Biol. 2006, 358:420-9.

32. Billingsley M.L., Yun J., Reese B.E., Davidson C.E., Buck-Koenthop B.A., Veglia G. “Functional and Structural Properties of Stannin: Role in Cellular Growth, Selective Toxicity, and Mitochondrial Responses to Injury.J. Cell. Biochem. 2006, 98:243-50.

31. Buck-Koenthop B.A., Mascioni A.,  Veglia G.Structure, Dynamics, and Membrane Topology of Stannin: A Mediator of Neuronal Cell Apoptosis Induced by Trimethyltin Chloride.J. Mol. Biol. 2005, 354:652-65.

30. Zamoon J. Nitu F. Thomas D. D., Veglia G.Mapping the Interaction Surface of a Membrane Protein: Unveiling the Conformational Switch of Phospholamban in Calcium Pump Regulation.Proc. Natl. Acad. Sci. USA 2005, 102: 4747-4752. PMCID: PMC555693

29. Metcalfe E.E., Traaseth N., Veglia G.Serine 16 Phosphorylation induces an Order-to-Disorder Transition in Monomeric Phospholamban.Biochemistry 2005, 11: 4386-4396.

28. De Silva T.M., Veglia G., Opella S.J.Solution structures of the reduced and Cu(I) bound forms of the first metal binding sequence of ATP7A associated with Menkes disease.Proteins 2005, 61(4):1038-49.

27. Mascioni A., Eggimann B.L., Veglia G.Determination of Helical Membrane Protein Topology Using Residual Dipolar Couplings and Exhaustive Search Algorithm: Application to Phospholamban.Chem. Phys. Lipids 2004, 132:133-144.

26. Buck B.A., Mascioni A., Cramer C.J., Veglia G.Interactions of Alkyltin Salts with Biological Dithiols: Dealkylation and Induction of a Regular Beta-Turn Structure in Peptides.J. Am. Chem. Soc. 2004, 126: 14400-14410.

25. Porcelli F., Buck B., Dong-Kuk Lee D-K, Hallock K.J., Ramamoorthy A.,  Veglia G.Structure and Orientation of Pardaxin Determined by NMR Experiments in Model Membranes.J. Biol. Chem. 2004, 279:45815-45823.

24. Metcalfe E.E., Zamoon J., Thomas D. D., Veglia G. "1H/15N Heteronuclear NMR Spectroscopy Shows Four Dynamic Domains for Phospholamban Reconstituted in Dodecylphosphocholine Micelles.Biophys. J. 2004, 87:1-10.

23. Buck B., Mascioni A., Que L. Jr., Veglia G.Dealkylation of Organotin Compounds by Biological DiThiols: Toward the Chemistry of Organotin Toxicity.J. Am. Chem. Soc. 2003, 125: 13316-13317. Research on trialkyltins featured in the Science Concentrates section of the November 10, 2003 issue of Chemical & Engineering News, 81: 44 (2003).

22. Mascioni A., Veglia G.Theoretical Analysis of Residual Dipolar Couplings in Regular Secondary Structure of Proteins.J. Am. Chem. Soc. 2003, 125(41): 12520-12526.

21. Zamoon J., Mascioni A., Thomas D. D., Veglia G.NMR Solution Structure and Topological Orientation of Monomeric Phospholamban in Dodecylphosphocholine Micelles.Biophys. J. 2003, 85: 2589-2598.

20. Mesleh M.F., Sangwon L., Veglia G., Thiriot D.S., Marassi F. M., Opella S. J.Dipolar Waves Map the Structure and Topology of Helices in Membrane Proteins.J. Am. Chem. Soc. 2003, 125: 8928-8935.

19. Buck B., Zamoon J., Kirby T. L., DeSilva T. M., Karim C., Thomas D., Veglia G.Overexpression, Purification and Characterization of Recombinant Ca-ATPase Regulators for High-Resolution Solution and Solid-State NMR Studies.Protein Expression Purif. 2003, 30: 253-261.

18. Mascioni A., Porcelli F., Ilangovan U., Ramamoorthy A., Veglia G.Conformational Preferences of the Amylin Nucleation Site in SDS Micelles.Biopolymers 2003, 69: 29-41.

17. Mesleh M. F., Veglia G., DeSilva T.M., Marassi F.M., Opella S.J. "Dipolar Waves as NMR Maps of Protein Structure." J. Am. Chem. Soc. 2002, 124: 4206-4207.

16. Mascioni A., Karim C., Zamoon J., Thomas D. D., Veglia G. "Solid-State NMR and Rigid Body Molecular Dynamics to Determine Domain Orientations of Monomeric Phospholamban." J. Am. Chem. Soc. 2002, 124: 9392-9393.

15. Opella S.J., DeSilva T.M., Veglia G. “Structural Biology of Metal Binding Sequences.Curr. Opin. Chem. Biol. 2002, 6: 217-223.

14. Mascioni A., Karim C., Barany G., Thomas D. D., Veglia G.Structure and Orientation of Sarcolipin in Lipid Environments.Biochemistry 2002, 41: 475-482.

13. Iovine P.M., Veglia G., Furst G., Therien M. J.High-Resolution Structure and Conformational Dynamics of Rigid, Cofacially Aligned Porphyrin-Bridge-Quinone Systems as Determined by NMR Spectroscopy and Ab Initio Simulated Annealing Calculations. J. Am. Chem. Soc. 2001, 123: 5668-5679.

(Work carried out prior to the University of Minnesota.)

12. Bozzi M., Veglia G., Paci M., Sciandra F., Giardina B., Brancaccio A. “A Synthetic Peptide Corresponding to the 550-585 Region of alpha-Dystroglycan Binds beta-Dystroglycan as Revealed by NMR Spectroscopy.” FEBS Letters 2001, 24979: 1-5.

11. DeSilva T. M., Veglia G., Porcelli F., Prantner A. M.,  Opella S. J. “Selectivity in Heavy Metal-Binding to Peptides and Proteins.” Biopolymers 2002, 64: 189-192.

10. Veglia G., Zeri A. C., Che M., Opella S. J. “Deuterium/Hydrogen Exchange Factors Measured by Solution NMR Spectroscopy as Indicators of the Structure and Topology of Membrane Proteins.” Biophys. J. 2002, 82: 2176-2183.

9.   Valentine K. G., Liu S., Marassi F. M., Veglia G., Opella S. J., Ding F., Wang S., Arshava B., Becker J. M., Naider F. “Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccaromyces Cerevisae alpha-Factor Receptor on Phospholipid Bilayers.” Biopolymers 2001, 59: 243-256.

8.   Veglia G., Opella S. J. “Lanthanides Ion Binding to Adventitious Sites Aligns Membrane Proteins in Micelles for Solution NMR Spectroscopy.” J. Am. Chem. Soc. 2000, 122: 11733-11734.

7.   Veglia G., Porcelli F., De Silva T. M., Prantner A., Opella S. J. “The Structure of the Metal-Binding Motif GMTCAAC Is Similar in an 18-residue Linear Peptide and the Mercury Binding Protein MerP.” J. Am. Chem. Soc. 2000, 122: 2389-2390.

6.   Coiro V.M., Segre A.L., Di Nola A., Paci M.,  Grottesi A., Veglia G., and Ballio A. "Solution Conformation of the Pseudomonas Syringae MSU 16H Phytotoxic Lipodepsipeptide Pseudomycin A Determined by Computer Simulations Using Distance Geometry and Molecular Dynamics from NMR Data." Eur. J. Biochem. 1998, 257: 449-456.

5.   Veglia G., Delfini M., Del Giudice M.R., Gaggelli E., Valensin G.; "1H NMR Studies on beta-Carboline Derivatives Interacting with Human Serum Albumin as a Model of the Benzodiazepine Receptor." J. Magn. Res. 1998, 130: 281-286.

4.   D'Alagni M., Delfini M., Di Nola A., Eisemberg M., Paci M., Roda L. G., Veglia G. "Conformational Study of [Met5]Enkephalin-Arg-Phe in the Presence of Phosphatidylserine Vesicles." Eur. J. Biochem. 1996, 240: 540-549.

3.   Brosio E., Delfini M., Veglia G., Pizzoferrato L. "Kinetics of the Enzymatic Degradation of Myo-Inositol Hexakisphosphate Studied by 31P NMR Spectroscopy. The Influence of Temperature." Quart. Magn. Res. Biol. Med. 1994, 1:135-140.

2.   Brosio E., Barbieri R., Manetti C., Veglia G., Delfini M.; "Biomaterials for Contact Lenses: Poly (2-Hydroxyethyl-Methacrylate/ Methacrylate) Copolymer Hydrogel. A Study by 1H and 23Na NMR Dynamic Parameters." Quart. Magn. Res. Biol. Med. 1994, 1: 35-38.

1.   Pagani Zecchini G., Paglialunga Paradisi M., Torrisi I., Lucente G., Gavuzzo E., Mazza F., Paci M., Sette M., Di Nola A., Veglia G., Traniello S., Spisani S. "Synthesis, Conformation and Activity of HCO-Met-deltaz Leu-Phe-OMe, an Active Analogue Chemotactic N-Formyltripeptides." Biopolymers 1993, 33: 437-451.